![]() We conducted the Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan (SAVE-J) trial, and showed that patients with refractory OHCA and VF/pVT on initial electrocardiogram (ECG) who received ECPR have more favorable neurological outcomes at 6 months compared with patients who received conventional CPR (CCPR). 1īased on a previous review of extracorporeal cardiopulmonary resuscitation (ECPR) after out-of-hospital cardiac arrest (OHCA) in Japan that reported that an initial cardiac rhythm of ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT) is a significant predictor of survival, 2 OHCA patients with sustained VF/pVT may be the most promising ECPR candidates (UMIN000001403).Įxtracorporeal life support (ECLS) has been proposed as a type of cardiac resuscitation for patients in cardiac arrest without return of spontaneous circulation (ROSC) during ongoing cardiopulmonary resuscitation (CPR). Stratifying by cardiac rhythm, on multivariable mixed logistic regression analysis an ECPR strategy significantly increased the proportion of patients with favorable neurological outcome at 6 months in the patients with sustained VF/pVT (OR, 7.35 95% CI: 1.58–34.09), but these associations were not observed in patients with conversion to PEA/asystole. The proportion of ECPR patients with favorable neurological outcome was significantly higher in the sustained VF/pVT group than in the conversion to PEA/asystole group (20%, 25/126 vs. A total of 407 patients had refractory OHCA with VF/pVT on initial electrocardiogram. The primary endpoint was favorable neurological outcome, defined as Cerebral Performance Category 1 or 2 at 6 months. Patients were divided into 4 groups by cardiac rhythm and CPR group. ![]() We analyzed data from the Study of Advanced Life Support for Ventricular Fibrillation with Extracorporeal Circulation in Japan, which was a prospective, multicenter, observational study with 22 institutions in the ECPR group and 17 institutions in the conventional CPR (CCPR) group. We investigated whether patients with out-of-hospital cardiac arrest (OHCA) and sustained ventricular fibrillation/pulseless ventricular tachycardia (VF/pVT) or conversion to pulseless electrical activity/asystole (PEA/asystole) benefit more from extracorporeal cardiopulmonary resuscitation (ECPR). Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Centre Department of Advanced Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto Universityĭepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Centreĭepartment of Health Communication, Kyushu University Graduate School of Medical Sciencesĭepartment of Emergency and Critical Care Medicine, The University of TokyoĬardiovascular Centre, Nihon University Hospitalĭepartment of Emergency Medicine, Sidney Kimmel Medical College of Thomas Jefferson Universityĭepartment of Traumatology and Critical Care Medicine, Sapporo Medical University School of Medicineĭepartment of Emergency and Critical Care Medicine, Nippon Medical SchoolĮmergency and Critical Care Medical Centre, Teine Keijinkai HospitalĬardiovascular Centre, Sapporo Teishinkai Hospitalĭepartment of Emergency Medicine, Seirei Hamamatsu General Hospitalĭepartment of Emergency Medicine, Teikyo University
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